Leptin Resistance In Newborns

Origins of Neonatal Leptin Deficiency in Preterm Infants

This can lead to leptin deficiency during a time of rapid growth and development. Late preterm and term male infants have lower leptin levels than female infants (9 - 11), predisposing them to adverse developmental outcomes. Limited investigations have shown leptin levels may be higher in breastfed versus formula-fed term infants (12).

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5.2 Is metreleptin a cost effective treatment for obesity caused by congenital leptin deficiency when compared to normal treatment? • No studies were identified which investigated the cost-effectiveness of metreleptin treatment for congenital leptin deficiency.

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Preterm infants have low circulating levels of leptin , a key trophic hormone that influences growth and development. While the clinical importance of prematurity-associated leptin deficiency is undefined, recent preclinical and clinical investigations have shown that targeted enteral leptin supplementation can normalize neonatal leptin levels. We tested the hypothesis that, independent of ...